Challenging Tropical Diseases in Children

The Neglected Tropical Diseases (NTDs) of around 17 or more parasitic diseases and its related infections represent the most common illness. Population growth, urbanization, deficiencies in water and sanitation systems lead to re- emergence of tropical diseases says the study. Cases of Neuro-schistosomiasis, Neurocysticercosis, and Chagasic stroke are increasingly detected in western countries. Recently, Chikungunya virus adapted to Aedus albopictus is spread in Europe has been reported. Dengue fever is the second most common mosquito-borne disease after malaria, and every year more than 50 million cases of dengue fever resulting in 25,000 fatalities.

The pipelines for new drugs for these diseases have been dried for the past 3 decades due to the absence of commercial market. Recently, Metallo-β-lactamase has been isolated from Klebsiella pneumoniae, offering few treatment opportunities. Several vaccines, including vaccines against hookworm infection, schistosomiasis and leishmaniasis are in phase 1 and phase 2 clinical trials for product development. These would be used as “vaccine-linked chemotherapy” alongside drugs in a comprehensive treatment.

  • Progress and challenges

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