Neonatal and Congenital Infections

Newborn congenital infections have a variety of causes fluctuate from pregnancy to genetic malformations in utero. In many cases, however, a congenital anomaly may have no known cause. For e.g. the structural defect such as spina bifida is obvious at birth, whereas hemophilia a functional defect (a bleeding disorder) is not usually obvious until infancy or childhood. An estimation of about 270 000 deaths during the first 28 days of life were reported due to congenital anomalies globally.

Advanced interventions of the neonatal infection risk have further led to identification of several promising potential biomarkers that may translate to improved diagnosis, treatment, and prognosis of neonatal sepsis in the future. Very low birth weight is an important factor for neonatal infection. Microbial agents can be transmitted from the mother to the fetus either Trans placentally, haematogenously, or via the birth canal. Microbial agents may penetrate the placental barrier and contaminate the fetus, often leading with neonatal infections. Recent studies revealed that emerging pathogens are predominantly Gram positive, of which coagulase-negative staphylococci are the commonest organisms accounting for 45–75% of all late-onset bloodstream infections.

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